Assessment of Disease Progression in Children with Nephrotic Syndrome Using Atherogenic Indicators

Authors

Department of Biochemistry, College of Medicine, University of Kerbala, Kerbala, Iraq

Abstract

Background
The nephrotic syndrome (NS) raises the risk of atherosclerosis and endothelial
dysfunction. Endothelial dysfunction was measured and linked with dyslipidemia
and inflammatory markers in individuals with nephrotic syndrome. LDL-cholesterol,
total cholesterol, and fibrinogen are the most critical variables implicated in
endothelial dysfunction in the nephrotic syndrome.
Objective
The study’s goal was to evaluate atherogenic indicators as markers that can be
utilized to determine both atherogenic potential and cardio metabolic health.
Materials and methods
This study was designed as a case-control study, A total of 52 participants age
range (9-12) year with nephrotic syndrome.
Sample collection
Collected from Kerbala pediatric teaching hospital, Iraq. Serum lipid panel (Total
cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density
lipoprotein (LDL) and triglycerides (TG), renal function test (blood urea
and creatinine) albumin in serum and urine were all measured for the study
groups.
Results and conclusion
The results of the study showed a massive increasing in the mean levels of the
atherogenic indices in (NS) patients compared to the control group. Diagnostic
thresholds point of the atherogenic indices were indicated that most of the
measured indices shown a highly sensitivity and specificity toward the lipid
complication in (NS) case. In our point of view, theses indices provided novel
clues on the atherogenic mechanisms in such cases, which might reflect the
inflammatory signals more effectively than lipid panel.

Keywords

Files

Share

How to cite

Statistics