Document Type : Original Article
Authors
1
Nematology and Biotechnology Research Lab, Faculty of Agriculture, Fayoum University, Fayoum,
2
Modern University for Technology and Information, Cairo,
3
Department of Zoology, Faculty of Science, Al-Azhar University, Assiut
4
Departments of Medical Physiology, National Research Centre, Giza, Egypt
5
Departments of Dairy, National Research Centre, Giza, Egypt
6
Departments of dMedical Physiology, National Research Centre, Giza, Egypt
Abstract
Background and objective
As Elettaria cardamomum possesses wide phytochemical and biological activities;
therefore, this study aimed to evaluate the ameliorating efficiency of Elettaria
cardamomum ethanolic extract (ECEE) in Doxorubicin-induced cardiotoxicity.
Materials and methods
Male rats (150–180 g) were arranged into four groups (8 rats/group) as: (1) normal
rats act as control, (2) normal rats daily ingested with ECEE (100 mg/kg, dissolved
in water) four 28 days, (3) rats cardio-intoxicated intraperitoneally with Doxorubicin
(DOX) at a dose 2.5 mg/kg on alternate days for 14 days and (4) cardio-intoxicated
rats treated orally with ECEE for 28 days.
Results and conclusion
After 28 days of treatment, the results revealed that ECEE restored the cardiological,
hematological, and immunological deteriorations induced by Doxorubicin; this was
evidenced by the significant reduction of serum aminotransaminases (ALAT and
ASAT), lactate dehydrogenase, creatin kinase MB, total cholesterol, triglycerides,
tumor necrosis factor-alpha, interleukin-1β, caspase-3 andnuclear factorkappa-lightchain-
enhancer of activated B cells as well as cardiac malondialdehyde, nitric oxide
levels and cardiac DNA-fragmentation coupled with marked improvement in cardiac
reduced glutathione, superoxide dismutase and glutathione peroxidase.
Hematological indices and hemoglobin derivatives were markedly restored.
Moreover, the ECEE induced prominent cardio-histological regeneration. In
conclusion, ECEE possessed anti-cardio-hematotoxicities exhibition that could be
performed through the radical scavenging and antioxidant characteristics of its active
constituent’s especially high phenolic content, reflecting the promising potency of
ECEE as cardio protective supplement.
Keywords
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