Background Ulcerative colitis(UC)isatypeofchronicinflammatoryboweldiseaseinthecolon thatisstillofunknownaetiology.What is known, till now,isthatUCisconfinedtothe colonstartingattherectumandextendingproximallyforavariabledistancetill reaching the cecum,anddespiteUCisknowntohavevariousextracolonic presentations,theuppergastrointestinaltract(UGIT)isnotgenerallyconsidered as target organ. Aim ThecurrentstudyaimedtodescribeUGITclinical, endoscopic, and histopathologicalfindingsinadultEgyptianpatientswithUC. Patients and methods Thestudywasconductedon56UCpatients.IntheTropicalMedicineDepartment Faculty of Medicine, AinShamsUniversity.Allthepatientsweresubjectedtofull historytakingandthoroughclinicalexamination.UGITendoscopywasperformed onallpatientstostudytheendoscopicfindingsintheoesophagus, stomach, and duodenumandtotakebiopsiesforhistopathologicalexamination. Results Thecurrentstudyhasshownthat60.7%ofpatientshadgastroesophagealreflux diseaseuponesophagogastroduodenoscopywhilemicroscopicevaluationof oesophagealbiopsiesshowedthat50%ofthecaseswerehavingesophagitis. Regardinggastroduodenalaffection, UGITendoscopyrevealedthat91.1%ofthe patientshadgastritisand78.6%hadduodenitis, histopathological examination of thebiopsysamplesrevealedthat53.6%ofthecaseshadchronicnonspecific gastritis,33.9%ofthecasesshowedchronicgastritiswithhelicobacterpylori infectionand85.7%hadchronicnonspecificduodenitis.The present study showedthatUGITaffectionwasdiagnosedcollectivelyin96.4and87.5%ofthe casesbyendoscopyandbiopsy, respectively. Conclusion ThecurrentstudyhasprovedtheassociationbetweenUCandthepresenceof endoscopic findings in the esophagus, stomach, and duodenum.These findings wereconfirmedbyhistopathologicalexaminationofmucosalbiopsiestakenfrom the esophagus, stomach, and duodenum.
Elwakil, O., Hamed, W., Nada, O., & Badran, E. (2025). A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis. Egyptian Pharmaceutical Journal, 24(2), 141-151. doi: 10.21608/epj.2025.407379
MLA
Omar R. Elwakil; Waleed A. Hamed; Ola H. Nada; Ethar M. Badran. "A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis", Egyptian Pharmaceutical Journal, 24, 2, 2025, 141-151. doi: 10.21608/epj.2025.407379
HARVARD
Elwakil, O., Hamed, W., Nada, O., Badran, E. (2025). 'A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis', Egyptian Pharmaceutical Journal, 24(2), pp. 141-151. doi: 10.21608/epj.2025.407379
VANCOUVER
Elwakil, O., Hamed, W., Nada, O., Badran, E. A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis. Egyptian Pharmaceutical Journal, 2025; 24(2): 141-151. doi: 10.21608/epj.2025.407379
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