Bioactive lignans and other phenolics from the roots, leaves and seeds of  L. grown in Egypt

Aboutabl, Elsayed A.; El Mahdy, Mona E.; Sokkar, Nadia M.; Sleem, Amany A.; Shams, Manal M.

doi:10.7123/01.EPJ.0000415466.17860.6a

Bioactive lignans and other phenolics from the roots, leaves and seeds of L. grown in Egypt

Authors

10.7123/01.EPJ.0000415466.17860.6a

Abstract

Aim
Investigation of the phenolic constituents of roots, leaves and seeds of L. cultivated in Egypt.
Methods
Qualitative and quantitative analysis of lignans and other phenolics by LC-MS/MS and HPLC/PDA-LC-MS/MS, as well as evaluation of potential bioactivities.
Results and conclusions
LC-MS/MS of the ethyl acetate fractions from seeds, leaves and roots showed the presence of 13 phenolics, including lignans, distributed in the different organs. The following phenolics were identified: caffeic acid , genistein , biochanin A , luteolin , chlorogenic acid , materisenol , arctigenin , quercetin , cynarin , arctiin , lappaol A , rutin and lappaol F . Quantification of these compounds by HPLC-PDA-MS/MS showed that arctiin was the major compound in seeds. The antioxidant, antihepatotoxic, anti-inflammatory and cytotoxic activities of ethanolic extracts of the different organs were evaluated.

Keywords