Assessment of some synthesized novel 9-substituted tetrahydroacridine derivatives in diabetic disease management in rats

Abdel Megeed, Rehab M.; Ghanem, Hassan Z.; Kamel, Mohsen M.; Bakeet, Maged F.; Abdel-Hamid, Abdel-Hamid Z.

doi:10.4103/1687-4315.205833

Assessment of some synthesized novel 9-substituted tetrahydroacridine derivatives in diabetic disease management in rats

Authors

10.4103/1687-4315.205833

Abstract

Background and objective
9-Substituted 1,2,3,4-tetrahydroacridine derivatives, especially those bearing substituted aliphatic or aromatic amino groups at the position 9, have been widely used for treating some chronic diseases because of their role as acetylcholine esterase inhibitors. Therefore, some new substituted tetrahydroacridine derivatives were synthesized to investigate their efficiency as antidiabetic agents .
Materials and methods
Some new substituted tetrahydroacridine derivatives hybridized at their position 9 with nitrogen, oxygen, and/or sulfur heterocycles or sulfa drugs starting from the known intermediate compound 9-chlorotetrahydroacridine were synthesized. Biologically, these compounds were investigated for antidiabetic potentials using Wistar rats. Diabetes was induced using streptozotocin (45 mg/kg) and then biochemical assays and histopathological examinations were applied to assess the therapeutic efficiency and safety margins of these compounds.
Results and discussion
Biochemical and histopathological examinations demonstrated the efficiency and safety margins of these compounds . Different biochemical analyses and histopathological examinations were estimated in diabetic and treated groups as compared with the healthy one. Data listed in this study showed an acceptable improvement percentage in glucose level and α-amylase, liver function enzymes (glutamic pyruvic transaminase and glutamic oxaloacetic transaminase), and lipid profile (triglyceride, low-density lipoprotein, total cholesterol) parameters after treatment with new synthetic compounds. Histopathological examination showed regeneration of treated groups. 9-Sulfadiazine-tetrahydroacridine (9-SDTHA) derivative () was the most safe and efficient compound. The superiority of this compound may be because of the presence of a pyrimidine ring, which is the main constituent of DNA and RNA structure. These compounds could be suggested as antidiabetic agents.

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