Impact of benzodiazepines administration on selected biochemical parameters of albino Wistar rats ()

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Abstract

Background
Considerable information has been reported on the adverse effect of benzodiazepines on the brain, with limited information of their effects on biochemical parameters.
Aim
This study aimed to investigate the effect of diazepam and bromazepam on selected biochemical parameters of albino Wistar rats.
Materials and methods
Diazepam and bromazepam at concentrations of 0.0046 mg/100 g body weight, 0.0036 mg/100 g body weight, 0.0026 mg/100 g body weight, and 0.0016 mg/100 g body weight were administered, respectively, to rats on a daily basis. At the end of each week, total serum protein, glucose, urea, and creatinine levels were evaluated. Histopathological examination of the liver was also performed for signs of possible damage.
Results
Reductions in serum glucose and creatinine levels were observed in the first, second, third, and fourth weeks in rats administered diazepam and bromazepam at various doses. Both drugs showed similar effects and the reductions were only significant (<0.05) for creatinine, whereas total serum protein was elevated significantly (<0.05). No effect was observed in urea levels throughout the study period. Histopathological examination of the liver showed pronounced morphological alterations in structure, indicative of hepatic damage.
Conclusion
Although hematological parameters such as glucose and urea were not affected significantly, the observed hepatotoxicity could be indicative of possible induction of hepatic damage with consequent metabolic aberrations.

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Egyptian Pharmaceutical Journal
Volume 17, Issue 1
January 2018
Pages 40-47

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