Context Ketorolac (KT) is a NSAID, with multiple pharmacological activities having been reported. Aim To formulate chitosan nanoparticles of KT for assessing their potential in decreasing the growth of colon cancer cells. Materials and methods Chitosan nanoparticles of KT such as F1 and F2 have shown anticancer activity against SCC-29 cell lines. Furthermore, nanoparticles have been subjected to stability test at various pH, drug-release study, and in-vivo pharmacokinetics in Wistar rats. Results The nanoparticles were in the size range between 164 and 210 nm. The oral absorption of nanoparticles was relatively higher than the KT alone. Conclusion The prepared nanoparticle formulations showed better activity than KT alone.
Venu, K., Mondal, S., & Mondal, P. (2018). Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines. Egyptian Pharmaceutical Journal, 17(1), 53-59. doi: 10.4103/epj.epj_1_18
MLA
Kola Venu; Sumanta Mondal; Prasenjit Mondal. "Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines", Egyptian Pharmaceutical Journal, 17, 1, 2018, 53-59. doi: 10.4103/epj.epj_1_18
HARVARD
Venu, K., Mondal, S., Mondal, P. (2018). 'Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines', Egyptian Pharmaceutical Journal, 17(1), pp. 53-59. doi: 10.4103/epj.epj_1_18
VANCOUVER
Venu, K., Mondal, S., Mondal, P. Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines. Egyptian Pharmaceutical Journal, 2018; 17(1): 53-59. doi: 10.4103/epj.epj_1_18
)
View on SCiNiTO