Thiothymine in the synthesis of triazolotriazine and hydrazone compounds

Hassaneen, Hamdi M.; Saleh, Fatma M.; Mohamed, Yasmin S.; Awad, Enas M.

doi:10.4103/epj.epj_17_18

Thiothymine in the synthesis of triazolotriazine and hydrazone compounds

Authors

Abstract

Background and objectives
Fused triazine derivatives are known to be a very important class of compounds that have significant biological activities. Also, they showed a broad spectrum against leukemic cell lines and cancer cells. Our objective after such a study is, on one hand, to shed some light on the synthesis of triazolotriazine and hydrazone derivatives from the thiothymine compound and, on the other hand, to explore the biological activity of the isolated products from such reactions.
Materials and methods
Reaction of thiothymine and hydrazonoyl chloride in refluxing chloroform in the presence of triethylamine yielded triazolotriazine derivatives . The hydrazino derivative underwent condensation reactions with aldehydes, pyruvic acid, ethyl pyruvate, and ketones to give the corresponding hydrazone derivatives and , respectively. Antimicrobial activities of some newly synthesized compounds were studied using the diffusion plate method.
Results and conclusion
Both antibacterial and antifungal activities of the new synthesized compounds , , and were studied. Also, the minimum inhibitory concentration values for the highly efficient antibacterial compounds using the most sensitive microorganisms were determined.

Keywords