Synthesis, antioxidant, anticoagulant, and fibrinolytic activities of new isatin derivative

El-Serwy, Weam S.; Mohamed, Neama A.; El-Serwy, Walaa S.; Kassem, Emad M.M.; Shalaby, Al Shimaa G.

doi:10.4103/epj.epj_52_19

Synthesis, antioxidant, anticoagulant, and fibrinolytic activities of new isatin derivative

Authors

Abstract

Background
Isatin as a product was first obtained from the oxidation of indigo dye by nitric acid and chromic acids by Otto Linné Erdman and Auguste Laurent in 1841.
Objective
This study presents the synthesis of some new isatin derivatives and examines their biological activities.
Materials and methods
2-Cyano(5-nitro-2-oxoindolin-3-ylidene)acetohydrazide ( reacted with some reagents, namely, salicylaldehyde, phenyl isothiocyanate, ethyl chloroacetate, ethyl iodide, ethyl cyanoacetate, thioglycolic acid, phenyl isothiocyanate, malononitrile, and hydrazine hydrate to produce compounds respectively. Moreover, compound reacted with hydrazine hydrate to produce compound . Antimicrobial activities of some newly synthesized compounds were studied.
Results
Antioxidant, anticoagulant, and fibrinolytic activities of the new synthesized compounds () were studied. Compound exhibited highest fibrinolytic activity. On the contrary, compound exhibited highest anticoagulant activities. Moreover, it was noticed that compound exhibited highest antioxidant activity.
Conclusion
In summary, 14 novel isatin derivatives were synthesized and screened for their antioxidant, anticoagulant, and fibrinolytic activities. Some compounds displayed moderate-to-excellent activities such as antioxidant, anticoagulant, and fibrinolytic agents.

Keywords