Tryptase and chymase are potent proteases secreted by mast cells upon activation. These abundant mast-cell proteases are converted into catalytically active forms by dipeptidyl peptidase 1 (DPP1). DPP1 is one of the most important components to initiate chain reaction for triggering the inflammatory response mediating allergic diseases such as asthma and allergic rhinitis. DPP1 can remove the safety catch on various mast-cell proteases, including tryptase and chymase, and plays an essential role in controlling their activity. However, the exact role of DPP1 in mast-cell degranulation is still not fully recognized.
El-Feki, G., EL-Desouky, M., & Badway, M. (2021). Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer. Egyptian Pharmaceutical Journal, 20(4), 264-269. doi: 10.4103/epj.epj_50_21
MLA
Ghada M. El-Feki; Mohamed A. EL-Desouky; Mohamed A. Badway. "Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer", Egyptian Pharmaceutical Journal, 20, 4, 2021, 264-269. doi: 10.4103/epj.epj_50_21
HARVARD
El-Feki, G., EL-Desouky, M., Badway, M. (2021). 'Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer', Egyptian Pharmaceutical Journal, 20(4), pp. 264-269. doi: 10.4103/epj.epj_50_21
VANCOUVER
El-Feki, G., EL-Desouky, M., Badway, M. Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer. Egyptian Pharmaceutical Journal, 2021; 20(4): 264-269. doi: 10.4103/epj.epj_50_21
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