Formulation and evaluation of mucoadhesive tablets of furosemide by design of experiment

Thimmaraju, Manish K.; Sushma, Desai; Vidhya, Beebireddy; Jyothi, Aenugu; Gudas, Ganesh K.; Venu, Kola

doi:10.4103/epj.epj_29_21

Formulation and evaluation of mucoadhesive tablets of furosemide by design of experiment

Authors

Abstract

Aim and objective
The present investigation concerns with the development and evaluation of mucoadhesive tablets of furosemide, which were designed to prolong the gastric residence time after oral administration.
Materials and methods
Mucoadhesive tablets of furosemide were formulated using different mucoadhesive polymers such as locust bean gum, tamarind gum, and chitosan in various ratios for treatment of hypertension by using design of experiment.
Results and discussion
The tablets were evaluated for various parameters such as compatibility studies, drug content, weight variation, hardness, thickness, friability, swelling studies, drug-release studies, mucoadhesion strength, residence time test, and release rate kinetics. The release kinetics studies reveal that all formulations fit well with zero order, followed by Korsmeyer–Peppas, Higuchi, and the mechanism of drug release is erosion. After analysis of different evaluation parameters and drug-release kinetics, formulation code F16 was selected as a promising formulation for delivery of furosemide as a mucoadhesive gastroretentive tablet with best mucoadhesive strength and 98.76% cumulative percentage drug released at the 12th hour. Stability studies of the selected formulation were carried out to determine the effect of formulation additives on the stability of the drug and also to determine the physical stability of the formulation.
Conclusion
The stability studies were carried out at 40°C/75% RH for 90 days. There was no significant change in the physical property and weight variation, hardness, thickness, friability, drug-release studies, and mucoadhesion-strength drug content during the study period.

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