Efficacy of nitrous oxide-oxygen inhalation versus oral midazolam-promethazine as sedative agents in pediatric patients

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Abstract

Background
Managing difficult and uncooperative pediatric dental patients is a challenging task. Conscious sedation has been propagated as a pharmacological means for handling such situations.
Objective
To evaluate the effects of sedation using nitrous oxide-oxygen inhalation versus oral midazolam-promethazine in pediatric patients.
Patients and methods
A total of 100 pediatric patients were selected and divided into two equal categories: group 1 (midazolam-promethazine) and group 2 (NO-O). Ethical committee approval was obtained, and patients were assessed. Data collected were analyzed using an unpaired test.
Results
Duration of sedation was found to be statistically significant, and a higher duration was found for group 1. No significant differences were noted in the behavior rating scale with either of the combinations and in pulse oximeter readings.
Conclusion
Midazolam/promethazine is better in inducing longer sedation than NO/O.

Keywords

Egyptian Pharmaceutical Journal
Volume 21, Issue 4
October 2022
Pages 526-530

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