Zeolite intervention counteracts hepato-nephrotoxicity changes and regenerates insulin release in streptozotocin-induced diabetic rats

Sultan, Hussein A.; Ashry, Mahmoud; El-Bitar, Alaa M.H.; Moustafa, Mohsen A.

Zeolite intervention counteracts hepato-nephrotoxicity changes and regenerates insulin release in streptozotocin-induced diabetic rats

Authors

Abstract

Background and objective
Natural products from various sources tend to be potential candidates for drug discovery. Natural and synthetic zeolites are potentially useful biopharmaceuticals and bio-tools due to their unique and outstanding physical and chemical properties; therefore, this study aimed to estimate the hepatorenal preventive and insulin release restoration efficiencies of zeolite (natural and synthetic) in STZ-induced diabetic rats.
Materials and methods
Post inductions of hyperglycemia with a single (ip) dose of STZ (55 mg/kg), the rats were arranged into four groups (8 rats each): (I) normal control group, (II) STZ-diabetic rats, (III) STZ-diabetic rats treated orally with natural zeolite (300 mg/kg/day), and IV) STZ-diabetic rats treated with synthetic zeolite (300 mg/kg/day).
Results and conclusion
After 6 weeks of treatment of diabetic animals, both zeolite types markedly exhibited antidiabetic, anti-inflammatory, hepato-nephroprotective, and antioxidative stress effects that were monitored from the significant reduction in glucose, ALAT, ASAT, urea, creatinine, MDA, and NO values concomitant with a significant rise in insulin, GSH, SOD and CAT values, close to the corresponding values of normal ones. Also, both zeolites succeeded to modulate STZ-induced histological distortion. In conclusion, both zeolites exhibited multi-health benefits with promising potential against STZ-induced diabetes. This effect may be attributed to the antioxidant and free radical scavenging mechanisms of zeolites that were evidenced by hepatorenal protective activities.

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