Synthesis and Tumor Targeting Evaluation of new radiopharmaceuticals based on vanillin and gallic acid derivatives for tumor imaging

Document Type : Original Article

Authors

1 1Pharmaceutical chemistry department, faculty of pharmacy, Helwan University, Egypt

2 department of pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan University

3 Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority, PO13759, Cairo, Egypt

4 Pharmaceutical organic chemistry department, faculty of pharmacy, Helwan University, Egypt.

10.21608/epj.2025.377496.1089

Abstract

Radiopharmaceutical applications in tumor imaging are widely used nowadays. Radioisotopes alone cannot reach the tumor easily, so it can be linked to a carrier to deliver the radioisotope to the tumor site. Theses carriers could be peptides, antibodies or small chemical agents. In our study, gallic acid derivative (4) and vanillin derivative (6) were used as two targeting chemical agents to be linked with 99mTc to prepare 99mTc-4 and 99mTc-6, then these two radiopharmaceutical were injected into mice and T/NT results were recorded for both of 99mTc-4 and 99mTc - 6 after 15 min, 30 min, 60 min and 180 min. T/NT for 99mTc-4 and 99mTc-6 at 60 min 1.74 and 4.32 respectively compared with the reference value for T/NT 1.5. These can conclude that 99mTc-4 and 99mTc-6 have a powerful targeting toward tumor, so that these two chemical agents 4 and 6 are promising to be applied into radiopharmaceutical applications.

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